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Rubella transmission in pregnancy

Rubella Transmission CD

Transmission Rubella spreads when an infected person coughs or sneezes. Also, if a woman is infected with rubella while she is pregnant, she can pass it to her developing baby and cause serious harm. See Pregnancy and Rubella page to learn more Rubella can be a serious threat to your pregnancy, especially during the first and second trimesters. Having rubella during pregnancy increases the risk of: Congenital rubella syndrome (CRS) - This is a condition that happens when a mother passes rubella to her baby during pregnancy

Rubella | German Measles | Home | CDC

However, infection with rubella during pregnancy can have serious consequences for the fetus, and it remains an important diagnosis. In this article, we shall look the clinical features of rubella infection, its investigations, management and complications. Fig 1- Negatively-stained transmission electron micrograph (TEM) The virus is transmitted by direct droplet contact from nasopharyngeal secretions, replicates in the lymph tissue of the upper respiratory tract, and spreads hematogenously. Congenital infection occurs when maternal viremia allows hematogenous spread of the virus across the placenta. Rubella in pregnancy will be reviewed here mother was exposed to endemic rubella transmission during gestation, as supported by epidemiological or genotyping evidence. A chain of rubella virus transmission that is continuous for ≥ 12 months within a country is defined as an endemic transmission. » Imported CRI/CRS: A confirmed case whose mother was exposed to rubella outside of th Both the chance of transmission of rubella to the fetus during pregnancy and the consequences of the infection to the unborn baby are related to the stage of development of the fetus at the time of maternal infection. Maternal infection during the first 8 weeks of pregnancy results in an infection rate in the fetus of about 85% When rubella infection occurs during pregnancy, especially during the first trimester, serious consequences can result. These include miscarriages, fetal deaths/stillbirths, and severe birth defects known as CRS. The most common congenital defects are cataracts, heart defects, and hearing impairment

Rubella and pregnancy - March of Dime

Rubella is caused by a virus that's passed from person to person. It can spread when an infected person coughs or sneezes. It can also spread by direct contact with an infected person's respiratory secretions, such as mucus. It can also be passed on from pregnant women to their unborn children via the bloodstream Rubella is a highly contagious viral disease characterized by slight fever, mild rash and swollen glands. Although most cases are mild, if rubella is contracted early in pregnancy, it can spread from the mother to her developing baby through the bloodstream and result in birth defects and/or fetal death Rubella remains a common community infection and continues to be a risk to pregnant women who have either not been immunised or who have waning immunity. Four recent cases of rubella infection occurring in pregnancy highlight the potential risk to the developing foetus of both primary infection and reinfection Infection with rubella virus is most consequential in early gestation and can lead to miscarriages, stillbirths, and severe birth defects in infants. The risk of CRS is highest when a woman acquires rubella during the first 12 weeks of gestation. Congenital infection with rubella virus can affect many organ systems Measles in Pregnancy: Frequently Asked Questions. Measles, also known as rubeola, is a highly contagious viral illness. Vaccination rates have decreased over the past decade, so the incidence of measles has increased, with recent outbreaks in the Pacific Northwest and New York City. Measles infections during pregnancy do not cause birth defects.

The rubella virus is spread by contact with secretions from the nose or throat of an infected person. Therefore, rubella is easily spread between family members or between children who go to the same daycare or school. A pregnant woman can pass rubella on to her fetus because the virus is able to cross the placenta Perinatal infections account for 2% to 3% of all congenital anomalies. TORCH, which includes Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19), Rubella, Cytomegalovirus (CMV), and Herpes infections, are some of the most common infections associated with congenital anomalies. Most of There are no controlled data in human pregnancy. There is a risk of viral transmission to the fetus. Abnormalities suggestive of congenital rubella syndrome were not observed during a 10-year survey of 700 pregnant women who received rubella vaccine within 3 months before or after conception

Rubella Infection in Pregnancy - Management - TeachMeObGy

Congenital rubella is the infection of a foetus with rubella virus following the infection of the mother during pregnancy. 'Congenital' indicates that the foetus also becomes infected during pregnancy The recommendations on the management of possible exposure to rubella in pregnancy are based on the clinical guidelines Viral Rash in Pregnancy [], UK Standards for Microbiology Investigations. Investigation of Pregnant Women Exposed to Non-Vesicular Rash [], Rubella (German measles): guidance, data and analysis [], Rubella (German measles, three-day measles) [], Health protection in schools.

Rubella in pregnancy - UpToDat

  1. Rubella and rubeola are common viral exanthems that may affect women of reproductive age. Effective vaccination programs have greatly decreased their incidence. Although Rubella is a relatively innocuous illness for the nonpregnant patient, transplacental fetal infection with rubella can result in s
  2. Rubella infection in a woman in the first 8 to 10 weeks of pregnancy results in death of or damage to the fetus in up to 90% of cases. Multiple defects are common (for example, deafness, blindness, brain and heart damage, and mental handicap) and late complications are being increasingly recognised
  3. Congenital infection is most likely if the maternal infection occurs in the first 16 weeks of pregnancy, with congenital rubella syndrome occurring in all fetuses infected before the 11th week and in 35% of those infected at 13-16 weeks (Miller et al 1982). If infection occurs after 16 weeks of pregnancy, the risk of fetal damage is negligible
  4. Problems are rare after the 20th week of pregnancy. Rubella is usually spread from one person to the next through the air via coughs of people who are infected. People are infectious during the week before and after the appearance of the rash. Babies with CRS may spread the virus for more than a year
  5. Rubella is an RNA virus belongs to Rubivirus genus within the Matonaviridae family [] .The rubella virus is a human disease with no known animal reservoir and transmits to a healthy person through air droplet shed when an infected person sneezes or coughs [].Rubella symptoms are usually mild, and up to 50% of infections may be clinically in-apparent []
  6. The incubation period for rubella is 14-21 days. Transmission. Rubella spreads from person to person by respiratory secretions, possibly including aerosol transmission. 16,54 People are infectious from 1 week before the rash appears (see Symptoms of rubella) until 4 days after. 5

As of 2004, rubella was declared eliminated in the United States, and transmission of the rubella virus in the World Health Organization's Region of the Americas was halted in 2009. Globally, about 100,000 rubella cases were reported for 2012 in the member states to the World Health Organization, though it is probable that the number of. Pregnancy Complications, Infectious/prevention & control* Rubella/prevention & control* Rubella/transmission; Rubella Vaccine/adverse effects* Substances Intrauterine transmission occurred in greater than 50% during the 16 first weeks of pregnancy compared to in 17% during the 21st to 24th weeks. Rubella defects appeared in a declining rate from 5/6 congenitally infected during the first 12 weeks to 1/7 at weeks 15 and 16 Sixty pregnant women with clinical signs of rubella and specific rubella antibodies were studied between January 1999 and December 2002 in order to determine the intrauterine rubella transmission rate and the presence of the virus in amniotic fluid and fetal tissues by nested PCR

Rubella infection during pregnancy and congenital rubella syndrome When rubella infection occurs during pregnancy, especially during the first trimester, serious immunity may limit disease transmission and may help to rapidly raise the vaccination level in the target population D. Modes of transmission Rubella is transmitted person-to-person by direct or droplet contact with infectious nasopharyngeal secretions. Rubella virus can be transmitted vertically from mother to fetus during pregnancy. E. Incubation period The incubation period for rubella ranges from 12-23 days (average 17 days). F. Period of communicability 1 Congenital rubella infection and congenital rubella syndrome (CRS) are caused by infection in early pregnancy. From just before conception and during the first 8-10 weeks of gestation, rubella infection may result in multiple fetal defects in up to 90% of cases and often causes miscarriage or stillbirth

This calls for rubella screening and precautionary measures during pregnancy. lThe rate of transmission of the virus is very low with vaccination against the infection at an early age. This is what the government is doing. Complications. The most worrisome complications come when pregnant women contract rubella In the 1964-1965 rubella pandemic, an estimated 50,000 pregnant women in the United States were exposed to rubella in pregnancy, resulting in miscarriages, stillbirths, and 20,000 babies born with. A pregnant woman who gets rubella, especially in the first trimester, can miscarry or deliver her baby prematurely. The baby also might die after birth or develop birth defects. Up to 85 percent of babies that get rubella in the womb during the first trimester are born with some type of birth defect. But birth defects are rare if infection. Following introduction of the RA 27/3 rubella vaccine, the CDC established a registry for women who received rubella vaccine within three months of conception.15 Pregnancy outcomes in 683 vaccine. Rubella in pregnancy: intrauterine transmission and perinatal outcome during a Brazilian epidemic. Andrade JQ, Bunduki V, Curti SP, Figueiredo CA, de Oliveira MI, Zugaib M J Clin Virol 2006 Mar;35(3):285-91

Congenital Rubella Syndrome (CRS). Many will have hearing loss, cataracts, other eye conditions, and heart problems treatment and affect the child throughout their life. A baby's brain can also be affected. Rubella caught in the first ten weeks of pregnancy causes damage to nine out of ten unborn babies. The mother passes the virus on to he The role of the laboratory is crucial in the management of rubella infection during pregnancy. Rubella serological results must be interpreted with caution. Congenital rubella is a severe disease that should already be eliminated thanks to a very effective vaccine that has been developed. Rubella / transmission* Rubella Syndrome, Congenital.

Rubella infection in pregnancy is likely to cause fetal infection, which can result in miscarriage, fetal demise, and serious birth defects (e.g., cataracts, heart disease, deafness, intellectual. Introduction. Rubella virus infection is transmitted by respiratory droplets and causes a generally mild disease characterized by a rash and fever, primarily in children [].Although the disease affects both males and females, it is a disease of public health importance in pregnant women causing major problems such as spontaneous abortions, miscarriages, stillbirths, and congenital defects. Rubella is an acute, contagious viral infection. While rubella virus infection usually causes a mild fever and rash in children and adults, infection during pregnancy, especially during the first trimester, can result in miscarriage, fetal death, stillbirth, or infants with congenital malformations, known as congenital rubella syndrome (CRS) Contraction of rubella later in pregnancy reduces the risk and severity of symptoms. Second trimester infections are associated with deafness, retinopathy, microcephaly, and mental retardation, while third trimester infections are associated with intrauterine growth retardation. MODE OF TRANSMISSION: The virus is transmitted by aerosols. Nevertheless, outbreaks of rubella continue to occur in medical facilities and have become important in the transmission of the disease. Control of outbreaks requires isolation of infectious patients, assignment of immune staff only to infectious patients, exclusion from work of infectious personnel, special follow-up of pregnant women and.

  1. Mode of transmission of rubella virus Rubella is transmitted by droplet spread or direct contact with infectious patients. Infants with CRS shed the rubella virus in their nose, pharyngeal secretions and urine for months or even years. Period of communicability of rubella (German measles
  2. Rubella in Pregnancy 1. What every clinician should know. A major worldwide epidemic of rubella spread to the United States in 1964, resulting in 12 million cases of rubella, 11,000 fetal deaths.
  3. Report and investigate suspected rubella in pregnancy, exposure of a pregnant woman to is essentially free of risks of altering rubella transmission dynamics, whereas inadequately implemented childhood vaccination runs the risk of increasing the number of cases of CRS (16,17). Therefore, childhood rubella vaccin
  4. ority groups in the UK who may not have had the vaccine. Helen Bedford explains. PMID: 1647558
  5. Transmission Rubella transmission occurs from person to person through contact with infectious nasopharyngeal the urine of an infant with CRS. In the case of CRS, rubella virus may also be transmitted from mother to fetus during pregnancy. Incubation Period CRS is contracted during pregnancy

ICD-11. KA62.8 Congenital rubella syndrome - A disease caused by an infection with the rubella virus in utero. This disease presents with symptoms depending on the timing of infection of the fetus and may present with birth defects (such as hearing loss), or intrauterine growth retardation. Transmission is by vertical transmission 4. Identify contacts of the case and sites of potential transmission during the period of communicability. 5. Make appropriate recommendations to susceptible contacts, particularly pregnant women (see Section 6). 6. Enhance surveillance for additional cases. 7. Contact CDE immediately regarding all reports of suspected acquired rubella or CRS fo Pregnancy Complications, Infectious / diagnosis Pregnancy Complications, Infectious / virology Reverse Transcriptase Polymerase Chain Reaction Rubella / congenital Rubella / diagnosis* Rubella / transmission Rubella / virology Rubella virus / genetics. Rubella infection can also cause anomalies in the developing foetus. Congenital rubella syndrome, characterised by deafness, cataract, heart malformations, mental retardation etc., is likely to occur in infants born to women who got infected during the first 3 months of pregnancy. Mode of transmission

diagnosed with rubella during pregnancy: All pregnant women infected with rubella during pregnancy should be monitored to document the pregnancy outcome (e.g., termination, CRS, or normal infant) on Centers for Disease Control and Prevention (CDC) Form 71.17, Congenital Rubella Case Report Form, and forward to the Epidemiology Branch Rubella (German measles) is a worldwide, mild, exanthematous and highly infectious viral disease of children in unvaccinated populations. Its prominence and the rational for immunising against rubella is the high risk of congenital malformations associated with rubella infection during pregnancy, something first observed by Dr Norman McAlister Gregg during the rubella epidemic in Australia. The rubella virus. Mode of transmission. Rubella is transmitted by droplet infection and direct contact with nasopharyngeal secretions of infectious cases. Timeline. The typical incubation period is 14 to 17 days, up to 21 days. Rubella is communicable for about 7 days before and at least 4 days after rash onset

Rubella, or German measles, is an infection caused by the rubella virus. Symptoms are often mild, but if infection occurs during pregnancy, it can cause severe harm to the unborn child, including. vaccine documented and presence of a positive rubella titer, immunity to measles is likely ; in one study of 262 pregnant women in Canada, measles susceptibility was present in only 0.8% of rubella seropositive women, when tested via gold-standard plaque reduction neutralization test (PRNT).16 Several studies have shown lowe Rubella Immune Status. Preventing congenital Rubella infections is a public health priority. Nosocomial Rubella transmission is a major source of these infections; therefore, KHEL strongly concurs with policies currently advocated by the American Hospital Association and the U.S. Public Health Service concerning employee immunizations

Rubella, Congenital - NORD (National Organization for Rare

Please use one of the following formats to cite this article in your essay, paper or report: APA. Thomas, Liji. (2021, July 07). Mother-to-baby SARS-CoV-2 transmission in pregnancy possible but. The importance of rubella derives not from acute disease, which is usually quite mild, but the potentially devastating effects of in utero infections. A fetus infected early in pregnancy (especially first trimester) has a high probability of developing congenital rubella syndrome—a constellation of problems tha

German measles, also known as rubella, is a viral infection that causes a red rash on the body. Aside from the rash, people with German measles usually have a fever and swollen lymph nodes.The. Rubella (german measles) is a rare illness that causes a spotty rash. It usually gets better in about 1 week. It can be serious if you get it when you're pregnant. Check if you or your child have rubella. The main symptom of rubella is a red or pink spotty rash. The rash takes 2 to 3 weeks to appear after getting rubella Rubella Vaccination During Pregnancy . Considering the high transmission rates of rubella and that 20-50% of cases are asymptomatic but still represent a potential source of infection, it is. Childhood rubella infection in early pregnancy can lead to fetal death or congenital rubella syndrome (CRS) with multiple disabilities. Reduction of transmission via universal vaccination can prevent CRS, but inadequate coverage may increase CRS numbers by increasing the average age at infection However, doctors often recommend isolation from others — especially pregnant women — during the infectious period. If you contract rubella while you're pregnant, discuss the risks to your baby with your doctor. If you wish to continue your pregnancy, you may be given antibodies called hyperimmune globulin that can fight off the infection

Rubella Information For Healthcare Professionals CD

Adult to adult transmission of rubella vaccine virus is unknown. 1.6 The risks of mumps to immunocompromised individuals There are limited data on the outcome of mumps in immunocompromised patients Rubella, viral disease that runs a mild and benign course in most people. Although rubella is not usually a serious illness in children or adults, it can cause birth defects or the loss of a fetus if a mother in the early stages of pregnancy becomes infected. German physician Daniel Sennert firs A vertically transmitted infection is an infection caused by pathogens (such as bacteria and viruses) that use mother-to-child transmission, that is, transmission directly from the mother to an embryo, fetus, or baby during pregnancy or childbirth.It can occur when the mother has a pre-existing disease or becomes infected during pregnancy. Nutritional deficiencies may exacerbate the risks of. Rubella is a viral infection and is sometimes called German measles, although it is not related to measles itself. Most people with rubella experience a mild illness involving fever and rash. It is important as rubella illness during pregnancy may significantly affect the developing foetus

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Congenital Rubella Syndrome (CRS) Rubella is important because it can produce a constellation of anomalies in the developing foetus. Congenital rubella syndrome is an illness resulting from embryonic / foetal rubella virus infection. CRS occurs in up to 90% of infants born to women who are infected with rubella in the first 10 weeks of pregnancy Transmission is through direct contact with an infected person or droplet spread. Rubella can cause serious complications for pregnant women and their unborn baby. Symptoms of rubella include Rubella is generally mild in children and more severe but not life-threatening in adults. However, if a pregnant woman is infected with rubella, it can cause serious problems for the unborn child. In the United States, most children receive the measles-mumps-rubella (MMR) vaccine, and therefore the disease has become uncommon Rubella, also called German measles or 3-day measles, isn't a problem for most people.It causes a mild fever and rash that go away in a few days. Most kids get vaccinated for it with the MMR. Rubella is a viral illness that causes a mild fever and a skin rash. Rubella is spread through contact with fluid from the nose and throat. It starts with a low fever, runny nose, and diarrhea. Then a rash appears on the face, and spreads down the body. A child is most contagious when the rash is appearing

SIXTH Disease - Roseola

Congenital rubella syndrome - Wikipedi

each pregnancy. The ACIP voted for the updated recom mendation in October 2012. In 2014, there have been at least 27 confirmed cases of measles in Washington State. While the MMR (measles, mumps, rubella) vaccine is NOT recommended during pregnancy, it can be postpartum, even if the mother is breastfeeding. Pregnant patients should also b Rubella virus (Latin, rubella = little red) is also known as German Measles due to early citation in German medical literature. Infection during pregnancy can cause congenital rubella syndrome (CRS) with serious malformations of the developing fetus. This association between infection and abnormal development was first identified in 1941 infections during pregnancy that could potentially lead to mother-to-child transmission. In the case of rubella, susceptible mothers are identified. Effectiveness of antenatal screening as prevention As above, but extended to the factors influencing the implementation of measures to prevent the infection of th Rubella Respiratory secretions Droplet precautions Vaccine Contact precautions for congenital rubella The non-immune HCW, pregnant or not, should not care for rubella patients until vaccination is complete. The MMR vaccine and its component vaccines should not be given to women known to be pregnant. Reassign to avoid risk of exposure. Rubeol In April 2016 WHO announced that rubella transmission has been interrupted and Ireland is now considered free of endemic rubella. However the risk of transmission if the virus is re-introduced still exists. Rubella continues to occur in other countries. Worldwide, over 100 000 babies are born with Congenital rubella syndrome (CRS) every year

Rubella - Chapter 4 - 2020 Yellow Book Travelers' Health

rubella vaccine. Rubella vaccine stimulates the formation of antibody to rubella virus in over 95% of susceptible individuals. 10 The only effective control measure to prevent the transmission of the rubella virus is immunization. Both male and female susceptible HCWs are at risk of acquiring as well as transmitting rubella to others Anderson's research on the transmission of rubella showed the experimental disease was infective for susceptible contacts and that subjects with a history of rubella failed to develop the disease. Lancaster's careful examination of Australian institutional records and census data led him to discover a causal connection between rubella. Endemic transmission is defined as a chain of rubella virus transmission continuous for ≥12 months within the United States. Unknown source case: a case for which an epidemiological or virological link to importation or to endemic transmission within the U.S. cannot be established after a thorough investigation Abstract. Some infections are more serious in pregnant than non-pregnant women because of the potential for vertical transmission to the fetus or infant (eg, varicella, rubella, cytomegalovirus infection, toxoplasmosis and listeriosis) Historic achievement follows similar firsts against smallpox in 1971 and polio in 1994. Washington, D.C., 29 April 2015 (PAHO/WHO) - The Americas region has become the first in the world to be declared free of endemic transmission of rubella, a contagious viral disease that can cause multiple birth defects as well as fetal death when contracted by women during pregnancy

Rubella infection in pregnancy - PubMe

Measles, Mumps, and Rubella Chapters 13, 15, and 20 . Transmission. Direct contact with infectious droplets or by airborne spread. Direct contact with saliva or respiratory become pregnant (4) Born before 1957 (except rubella for women of childbearing age who coul PATHOGEN SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT. NAME: Rubella virus. SYNONYM OR CROSS REFERENCE: German measles Footnote 1-Footnote 5, 3 day measles Footnote 4, congenital rubella syndrome (CRS) Footnote 1-Footnote 5.. CHARACTERISTICS: Family Togaviridae, Genus Rubivirus. Each virion is 55-89 nm and contains one positive stranded RNA molecule

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Rubella - Symptoms and causes - Mayo Clini

Rubella is the first virus demonstrated as a teratogen. There is a high risk to develop congenital rubella syndrome (CRS) if the infection occurs in the first part of pregnancy, particularly in women without specific immunological protection. Specific therapies to prevent CRS are not available. Many developed countries have specific vaccination. U.S.: Centers for Disease Control and Prevention: Viral Hepatitis, Perinatal Transmission (2018) EU/EEA: Antenatal Screening for HIV, Hepatitis B, Syphilis and Rubella Susceptibility in the EU/EEA (2016) Globally: WHO Prevention of Mother-To-Child Transmission of Hepatitis B Virus: Guidelines on Antiviral Prophylaxis in Pregnancy (2020 Pregnancy or attempting to become pregnant - Women should be counseled to avoid becoming pregnant for 28 days after receiving MMR because of the theoretic risk of congenital rubella syndrome . Pregnant women without immunity to measles, mumps, and rubella should receive a dose of MMR postpartum mumps, or rubella should receive 1 dose of MMR unless they have a medical contraindication to the vaccine (e.g., pregnancy or severe immunodeficiency) • Pregnant women without evidence of immunity to rubella should receive 1 dose of MMR upon completion or termination of pregnancy and before discharge from the health care facilit

Rubella (German Measles or Three-Day Measles

No pregnant woman under 20 weeks' gestation should have rubella diagnosed on IgM alone. The laboratory should store (frozen) an aliquot of serum for later testing in tandem with a follow-up sample. If the sample is IgM positive, regardless of IgG, then a full assessment of the serological status is needed Complications of Rubella. The most serious of these could happen during pregnancy, when the virus can pass from mother to baby in the womb. The risk is highest during the first 3 months of pregnancy The efficiency of transmission varies depending on the organism and the trimester of pregnancy. In utero transmission of the Rubella virus and Toxoplasma gondii occurs only as a result of a primary infection, whereas CMV and HIV in utero infections have occured for multiple pregnancies

Rubell ppt

Rubella is however rare in the UK, and most women receive antenatal screening for rubella antibodies in the early stages of pregnancy. Advice on measures to reduce the risk of transmission The recommendation on avoiding contact with other pregnant women and at-risk groups is extrapolated from expert opinion in the PHE publication UK Standards. Rubella is a mild viral disease of little clinical significance in children and adult males. However, rubella infection in pregnancy is of major public health importance due to the teratogenic effects that can result from congenital rubella infection, which can lead to miscarriage, fetal death or birth of an infant with congenital rubella. If a pregnant woman contracts rubella, the unborn child may have some severe problems that can be fatal in some cases. Approximately 80% of the babies whose mothers had rubella during the first trimester of pregnancy develop a condition known as congenital rubella syndrome. This can cause problems including Rubella remains an important pathogen worldwide, with roughly 100 000 cases of congenital rubella syndrome estimated to occur every year. Rubella-containing vaccine is highly effective and safe and, as a result, endemic rubella transmission has been interrupted in the Americas since 2009. Incomplete rubella vaccination programmes result in continued disease transmission, as evidenced by recent. All suspected rubella and CRI/CRS cases should be reported as soon as possible to local public health units. Patients should be isolated for 4 days after the appearance of a rash in order to prevent transmission of the virus. All contacts of a suspected rubella case should be identified and classified as susceptible or non-susceptible Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China. This is a cross-sectional and hospital-based study. From June 2016 through March 2017, a total of 324 serum samples from healthy pregnant women were collected in.